ࡱ> y{x R(7bjbjyy>H(8;<w\0v(OOOOQQQQQQ$X!uuOOOOOuTCCCOOCOOCCCPr!^C;00C!f"C!LB"$COOCOOOOOuuCOOO0OOOOf"OOOOOOOOO+ : Drug Information Sheet("Kusuri-no-Shiori")InternalRevised: 06/2012The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.Brand name: THYRADIN-S TABLETS 25gActive ingredient: Levothyroxine sodium hydrateDosage form: Light red tablet, diameter: 6.5 mm, thickness: 2.4 mmPrint on wrapping:(face) 00000S25g, TZ214, 25g(back) THYRADIN- S 25g, 00000S 25gEffects of this medicineThis medicine is a thyroid hormone preparation and replaces thyroid hormone which is deficient due to thyroid disorder or a surgery. It is usually used in the treatment of hypothyroidism (primary or hypophyseal), myxedema, cretinism, and goiter.Before using this medicine, be sure to tell your doctor and pharmacist0If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have: myocardial infarction, cardiovascular or vascular disorders, adrenocortical insufficiency or pituitary gland disorder.0If you are pregnant or breastfeeding.0If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)Dosing schedule (How to take this medicine)0Your dosing schedule prescribed by your doctor is<< to be written by a healthcare professional>>0In general, for adults, take 25 to 400 g of levothyroxine sodium at a time, once daily. In general, start with taking 25 to 100 g and the dose will be increased gradually, however, the maintenance dose is 100 to 400 g at a time, once daily. The dosage may be adjusted according to the age or symptoms. This preparation contains 25 g of levothyroxine sodium in a tablet.0Strictly follow the instructions.0If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. 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If any of these symptoms occur, consult with your doctor or pharmacist.The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.0chest pain, pressure feeling, constricted feeling [angina pectoris]0general malaise, loss of appetite, yellowing in skin or white of eyes [hepatic dysfunction, jaundice]0general malaise, hypotension, decreased urine output [adrenal crisis]The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.Storage conditions and other information0Keep out of the reach of children. Store away from direct sunlight, heat and moisture.0Discard the remainder. Do not store them. 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